Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine.
Fishlock D, Williams RM.
Org Lett. 2006 Jul 20;8(15):3299-301.
Department of Chemistry, Colorado State University, Fort Collins 80523-1872, and University of Colorado Cancer Center, Aurora, Colorado 80045, USA.
[Structure: see text] The asymmetric synthesis of a highly functionalized tetrahydroisoquinoline relevant to the total synthesis of Et-743 is described. The key step involves a highly diastereoselective radical cyclization on a glyoxalimine derivative.
Grant Support:
CA85419/CA/NCI