Not only this, researchers are developing now cytotoxic agents that are insensitive to P-gp-mediated drug efflux. Lamellarin D (LAM-D), a marine alkaloid endowed with potent cytotoxic activities against various tumor cells, in particular, human prostate cancer cells and leukemia cells, is one such addition. LAM-D acts as a potent proapoptotic agent and its cytotoxic action is fully maintained in multidrug-resistant cells compared with the sensitive parental cell line.
MDR1/P-gp not only causes multidrug resistance in cancer but has been found responsible for MDR of many other drugs.
PD :
Las Lamellarins son una familia de alcaloides poliaromáticos presentes en una esponja que han demostrado tener actividad frente a diversas líneas de células tumorales humanas e inhiben selectivamente a la topoisomerasa I, una diana clave en el tratamiento contra el cáncer. También parecen bloquear la maquinaria celular natural responsable de la resistencia a múltiples fármacos.