Pharma Mar y Genentech ... o mejor dicho Irvalec en Combinación con Erlotinib muestran Synergias en el Peor de los Cancers ... el de Pulmón .

April 2009 .
Molecular pharmacodynamics of PM02734 (elisidepsin) as single agent and in combination with erlotinib; synergistic activity in and xenograft models.
Ling YH, Aracil M, Jimeno J, Perez-Soler R, Zou Y.
Division of Medical Oncology, Albert Einstein College of Medicine, Bronx, New York, USA.

PM02734 (elisidepsin) is a novel marine-derived cyclic peptide belonging to the Kahalalide family of compounds currently under phase I development with early evidence of a positive therapeutic index. The cytotoxicity of PM02734 has been determined in a panel of human NSCLC (non-small cell lung cancer) cell lines. Western blot analysis showed a direct correlation between ErbB3 expression and cell sensitivity to PM02734. Furthermore, PM02734 was more effective in the induction of ErbB3 degradation and dephosphorylation than in that of ErbB2 and ErbB1 in human NSCLC cell lines. The combination of PM02734 and erlotinib was synergistic in all NSCLC cell lines tested, including erlotinib resistant cell lines, with combination indexes ranging between 0.59 and 0.81. The combination of PM02734 and erlotinib was more effective than either drug alone in mice inoculated intravenously (i.v.) with A549 cells. The combination of PM02734 and erlotinib was more effective in inhibiting AKT than either single agent alone in H322 cells. These results have provided a rational basis for an ongoing clinical trial to explore this combination in patients with advanced malignant solid tumours.

Zeltia supera el kumo, objetivos de corto 3.82 .

J & J Presenta Resultados del Yondelis en Cancer de Prostata Fase II en el ASCO Genitourinary Cancers 2009 .

Conclusions: Trabectedin administered at 1.2 mg/m2 every 3 weeks resulted in confirmed 50% PSA decline in 18% in men with CRPC who had received prior taxane chemotherapy (Cohort B), a rate comparable to the 14% shown by taxane-resistant men from Cohort A. Most common adverse effects were myelosuppression, transaminitis, nausea and fatigue. Ongoing translational studies are designed to identify pts most likely to benefit from trabectedin treatment.