19 febrero 2025
Atezolizumab Induced Generalized Cutaneous Lichen Planus in a Patient With Metastatic Small Cell Lung Cancer Successfully Treated With Isotretinoin : A Case Report .
17 FEBRUARY 2025 .
Immune checkpoint inhibitors, now widely used in treating various malignancies, increase the risk of autoimmune reactions and immune-related adverse events (irAEs), with skin toxicities being the most frequent .
These agents enhance the immune response against tumors by blocking the suppression of cytotoxic T lymphocytes .
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After consulting with the oncologist, we opted to initiate isotretinoin as the first-line treatment .
Considering the patient's oncologic status and multiple comorbidities, we aimed to avoid systemic corticosteroids due to their potential side effects .
This case was effectively managed with low-dose oral isotretinoin alongside high-potency topical corticosteroids. It emphasizes the need to consider retinoids as a potential treatment option for various dermatological conditions beyond acne .
Isotretinoin may be beneficial in treating lichen planus by influencing cellular proliferation and promoting epithelial differentiation, though its exact mechanism remains uncertain .
Additionally, it has notable anti-inflammatory effects and modulates immune responses. In such cases, isotretinoin may also enhance the therapeutic effects of topical corticosteroids through a synergistic interaction .
Trump : Sectorial Tariffs on PHARMACEUTICALS and SEMICONDUCTOR CHIPS Would Also Start at " 25% or Higher ", Rising Substantially Over The Course Of a Year .
Trump Says He Will Introduce 25% Tariffs on AUTOS , PHARMACEUTICALS And CHIPS .
Pharma, Chip Firms May Face Tariffs Above 25%, Timing Uncertain .
He Did Not Provide A Date For Announcing Those Duties And Said He Wanted To Provide Some Time For Drug And Chip Makers To Set Up U.S. Factories So That They Can Avoid Tariffs . ...
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