14 abril 2020
Coronavirus.- El Gobierno toma el control de los centros privados que realizan test y regulará los precios .
MADRID, 14 Abr. (EUROPA PRESS) -
El Gobierno ha puesto en disposición de las comunidades autónomas todos los centros clínicos de titularidad privada que realizan test de coronavirus y se ha adjudicado la posibilidad de adoptar desde este martes las medidas necesarias para la regulación de los precios de las pruebas con el objeto de evitar situaciones abusivas en el acceso a este servicio. ...
Vanquishing the Virus: 160+ COVID-19 Drug and Vaccine Candidates in Development .
Scientists Worldwide are Racing to Develop more than 160 New Drug and Vaccine Candidates to Combat the Pandemic, GEN Reports in a Comprehensive New A-List .
By Alex Philippidis -April 13, 2020
...
Pharmamar
Candidate: Aplidin® (plitidepsin)
Type: Anticancer agent of marine origin, originally obtained from the ascidian Aplidium albicans. It specifically binds to the eEF1A2 and targets the non-canonical role of this protein, resulting in tumor cell death via apoptosis (programmed death).
Status: PharmaMar on April 2 said it it submitted its protocol for the Phase II APLICOV clinical trial of Aplidin to the Spanish Medicines and Healthcare Products Agency (AEMPS). The planned 160-patient trial would be a multicenter, randomized study in which two different doses of plitidepsin will be evaluated in hospitalized patients with COVID-19 pneumonia, to assess whether plitidepsin, administered intravenously for 5 days, reduces the proportion of patients who progress to Acute Respiratory Distress Syndrome (ARDS).
In March, PharmaMar announced the results of in vitro studies of plitidepsin in human coronavirus HCoV-229E, with a mechanism of multiplication and propagation that is very similar to that of SARS-CoV-2. The studies were carried out at the National Biotechnology Centre of the Spanish National Research Council (CSIC; Centro Nacional de Biotecnología). The studies confirmed that the therapeutic target of Aplidin, EF1A, is key to the multiplication and spread of the virus.
By Alex Philippidis -April 13, 2020
...
Pharmamar
Candidate: Aplidin® (plitidepsin)
Status: PharmaMar on April 2 said it it submitted its protocol for the Phase II APLICOV clinical trial of Aplidin to the Spanish Medicines and Healthcare Products Agency (AEMPS). The planned 160-patient trial would be a multicenter, randomized study in which two different doses of plitidepsin will be evaluated in hospitalized patients with COVID-19 pneumonia, to assess whether plitidepsin, administered intravenously for 5 days, reduces the proportion of patients who progress to Acute Respiratory Distress Syndrome (ARDS).
In March, PharmaMar announced the results of in vitro studies of plitidepsin in human coronavirus HCoV-229E, with a mechanism of multiplication and propagation that is very similar to that of SARS-CoV-2. The studies were carried out at the National Biotechnology Centre of the Spanish National Research Council (CSIC; Centro Nacional de Biotecnología). The studies confirmed that the therapeutic target of Aplidin, EF1A, is key to the multiplication and spread of the virus.
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