Myeloma Multiple . La Combinación de 3 Farmacos : Zalypsis ( PharmaMar ) ,Velcade ( J&J ) y Dexamethasone Reducen Drasticamente el Volumen del Tumor .

Zalypsis Has Synergistic Effect When Combined with Velcade (Bortezomib)+ Dexamethasone through Caspase Dependent and Mainly Independent Mechanisms and through A Potent Induction of DNA Damage


The study of the mechanism of action is currently being completed and final results will be presented at the meeting.


In summary, the combination of zalypsis + Velcade (bortezomib)+ dexamethasone shows high synergy in MM through the activation of different pathways, and these results provide the rationale for its use in relapsed/refractory MM patients.








Combinación de Zalypsis® + Bortezomib+ Dexametasona, ha mostrado una alta Sinergia in vitro e in vivo para Mieloma Múltiple a través de la activación de diferentes mecanismos, como daño de ADN, Apoptosis Dependiente de Caspasa y Activación Mitocondrial.

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