USE OF PARP-1 INHIBITORS
Publication number: WO2007062413
Publication date: 2007-05-31
Inventor: SCOTTO KATHLEEN A (US); MANDOLA MICHAEL (US)
Applicant: UNIV NEW JERSEY MED (US); SCOTTO KATHLEEN A (US); MANDOLA MICHAEL (US)
Classification:
- international: A61K31/7076; A61K31/498; A61K31/7042; A61K31/498;
- European:
Application number: WO2006US61254 20061127
Priority number(s): US20050739536P 20051125
Abstract of WO2007062413
A method for improving the cytotoxic effect of Ecteinascidin-743 (ET-743) or an analog thereof on a tumor cell population in a patient the method including administering to the patient, sequentially or simultaneously, a therapeutically effective combination of a composition including ET-743 and an amount of a composition including a PARP-I inhibitor effective to increase the cytotoxic effect of ET-743 on the tumor cell population. Anti-tumor compositions containing a therapeutically effective amount of ET-743 and an amount of a PARP-I inhibitor effective to increase the tumor cytotoxicity of the ET-743 are also presented.