ANTITUMORAL ANALOGS OF ET-743, PHARMACEUTICAL COMPOSITION BASED THEREON AND USE THEREOF .
Publication number: UA78680 Publication date: 2007-04-25 Inventor: MARTIN MARIA JESUS (ES) Applicant: PHARMA MAR SA (ES) Classification: - international: A61K31/499; A61P31/04; A61P35/00; C07D471/18; C07D471/22; C07D487/18; C07D491/22; C07D515/00; A61K31/499; A61P31/00; A61P35/00; C07D471/00; C07D487/00; C07D491/00; C07D515/00; - European: Application number: UA20021210092 20010515 Priority number(s): WO2000GB01852 20000515; WO2001GB02110 20010515
Abstract of UA78680 Antitumour compounds have the five membered fused ring ecleinascidin structure of the formula (XIV). The present compounds lack a 1,4-bridging group as found in the ecteinascidins. They have at the C-1 position a substituent selected from an optionally protected or derivatised aminomethylene group or an optionally protected or derivatised hydroxymethylene group. , (XIV)