31 mayo 2015

City of Hope Ovarian Cancer Research and Clinical Trials .

May 30, 2015 22:59·

In collaboration with physicians and scientists at the National Cancer Institute, Food and Drug Administration, and other centers of academic excellence, the Program is committed to developing effective means for the accurate detection of women at risk with the ultimate goal of detecting pre-malignant disease and prevention. By answering specific questions a woman will be told her risk for developing specific cancers such as gynecologic, breast and colon cancers, and how to change those risks. About 10% of women who have ovarian cancer have it without ovaries present in the body. Nearly 3 of 4 women diagnosed with ovarian cancer survive a year after being diagnosed and nearly half of those women live longer than 5 years. This makes ovarian cancer the fourth most common cause of death of women from cancer. Sometimes in the early stages of ovarian cancer, a woman can still conceive, because only one ovary will be removed.

In the meantime, Orofino continues to spread the word about the symptoms of ovarian cancer. The way the radiation therapy is given depends on the type and stage of the cancer being treated.

There are many factors that may increase your risk of ovarian cancer. They traveled together to Uganda last fall to meet with their counterparts at the Uganda Cancer Institute and to immerse themselves in shaping their research.


Ovacome is United Kingdom wide support group for anyone affected by ovarian cancer. This approach to cancer therapy has proven successful in other cancer types and is likely to prove fruitful for ovarian cancer. Researchers are currently examining whether drugs called checkpoint inhibitors may boost the immune system's ability to destroy cancer cells.

The results of this study will shift the paradigm for ovarian cancer treatment from one that treats patients solely with chemotherapy that targets the rapidly proliferating cells to one that targets both the rapidly proliferating "bulk tumor" cells and the quiescent CSC. The p53 gene plays a key role in controlling cell growth, high frequency of p53 mutations in ovarian cancers and the potential of ovarian cancer to remain confined to the pelvic cavity. It has been shown, however, that removal of all visible manifestations of the tumor (often referred to as debulking surgery), followed by chemotherapy treatment, provides the best chance of a cure. When gefitinib is used in patients with lung cancer, researchers discovered that only patients whose tumors contained specific mutations responded to this drug.

The Drugs Trabectedin ( Yondelis® ) and Belotecan have shown promise in some studies.

HER-2/neu oncogene studies. In collaboration with Dr. Dennis Slamon, the research laboratory is studying the HER-2/neu oncogene as it relates to regulating steroid hormones in females with ovarian cancer.

When the drugs cisplatin and carboplatin stop working, the cancer is said to be platinum resistant. The International Newsleter for Those Fighting Ovarian Cancer, as a service to inform the public of available resources. So, the trial needs many patients to be able to show the difference. Research going on now is looking at the combined use of Avastin and chemotherapy. While most women will achieve complete remission after treatment (surgery and chemotherapy), the majority will relapse within two years, highlighting the need for novel therapies.