PM060184 y PM050489 Isolation and First Total Synthesis . Cancer Fighters From The Sea . The Molecules appear to interfere with Microtubules, which are Structures that are key to Cell Division .

PM060184 & PM050489：来自海洋的抗癌新药（修改稿）

Maria Jesús Martín , Laura Coello , Rogelio Fernández , Fernando Reyes , Alberto Rodríguez , Carmen Murcia , María Garranzo , Cristina Mateo , Francisco Sánchez , Santiago Bueno , Carlos de Eguilior , Andres M. Francesch , Simon Munt , and Carmen Cuevas .
Copyright © 2013American Chemical Society .Volume 91 Issue 25 . News of The Week . Issue Date: June 24, 2013 .

Keywords: PharmaMar, tubulin, PM060184, PM050489, sea sponge .

PM60184 is currently being tested in clinical trials for safety and efficacy.“When you discover a new chemical such as this, and you synthesize it and put it in clinical trials, it’s the realization of the dream of working in pharmaceutical R&D,” says Carmen Cuevas, PharmaMar’s director of R&D, who spearheaded the project.
Ian Paterson, a polyketide expert at Cambridge University, says that “while these are still early days, it is hoped that a successful anticancer drug emerges from this work and it stimulates further research in marine natural products for drug discovery.”

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Entender los microtúbulos ayudará a avanzar en las enfermedades complejas.