P.D.: Los investigadores del Cáncer han encontrado que la Metástasis depende de la cooperación de una subpoblación de Macrófagos, una asociación que se puede romper mediante Interacciones con Drogas apropiadas . “Esto sugiere que una Terapia antiMacrófagos tendría un Impacto en los Pacientes aún con Enfermedad Metastásica”, dijo el Dr. Pollard. “Los Macrófagos mismos, o sus vías de señalización únicas representan Blancos Terapéuticos nuevos que pueden ser Eficaces para Reducir la Mortalidad del Cáncer”.Una de estas Drogas podría ser el Yondelis según lo publicado por Cientificos Italianos :
Role of Macrophage Targeting in the Antitumor Activity of Trabectedin .
http://www.sciencedirect.com/science/journal/15356108/23/2
There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusively in mononuclear phagocytes. In four mouse tumor models, trabectedin caused selective depletion of monocytes/macrophages in blood, spleens, and tumors, with an associated reduction of angiogenesis. By using trabectedin-resistant tumor cells and myeloid cell transfer or depletion experiments, we demonstrate that cytotoxicity on mononuclear phagocytes is a key component of its antitumor activity. Monocyte depletion, including tumor-associated macrophages, was observed in treated tumor patients.
Trabectedin activates caspase-8-dependent apoptosis; selectivity for monocytes versus neutrophils and lymphocytes is due to differential expression of signaling and decoy TRAIL receptors.
This unexpected property may be exploited in different therapeutic strategies.
Copyright © 2013 Elsevier Inc. All rights reserved.
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La Nueva Propiedad del Yondelis recogida en la Prensa Italiana ... cada editorial con un analisis propio :http://www.repubblica.it/salute/ricerca/2013/02/12/news/farmaco_cellule_corrotte-52477493/
http://scienze.befan.it/trabectedina-un-farmaco-anti-tumore-dai-molluschi-marini/
http://www.bolognatg24.it/top-news/2013/02/13/40652/un-mollusco-marino-la-nuova-arma-contro-il-cancro/
http://www.italiasalute.it/2779/h/La-trabectedina-aggredisce-tumore-e-i-suoi-alleati.html
http://www.campanianotizie.com/attualita/mondo/51189-tumori-dai-caraibi-farmaco-che-uccide-poliziotti-corrotti-cancro.html
http://www.ogginotizie.it/214887-tumori-un-farmaco-dai-molluschi-marini/
http://scienze.fanpage.it/i-nuovi-effetti-antitumorali-di-un-farmaco-ricavato-dal-mollusco-marino/
http://www.healthdesk.it/ricerca/articolo/5828/1360693406
http://www.policliniconews.it/schede.cfm?id=511&Un_nuovo_farmaco_pu%C3%B2_bloccare_le_cellule_tumorali
http://notizie.tiscali.it/articoli/scienza/13/02/mollusco-marino-nuovo-farmaco-contro-tumori.html