J.Med Chem . 2006 Feb 9
Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.
Fresneda PM, Delgado S, Francesch A, Manzanares I, Cuevas C, Molina P
Departamento de Quimica Organica, Facultad de Quimica, Universidad de Murcia, Campus de Espinardo, 30100-Murcia, Spain, and PharmaMar, S. A., Avda. de los Reyes, 1, 28770-Colmenar Viejo, Madrid, Spain.
The marine alkaloid variolin B 2 and eight synthetic derivatives with different substituents at positions C-5 and C-7 have been tested in a panel of sixteen human tumor cell lines to evaluate their cytotoxic potential.