Title: Metabolites of ecteinascidin 743 formed by human cytochrome CYP3A4
Abstract: The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM" followed by a numeric value which represents the approximate molecular weight. Three compounds have been identified to date, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are as follows: ##STR1##
Patent Number: 6,867,334 Issued on 03/15/2005 to Rinehart, et al.
Inventors: Rinehart; Kenneth L. (Urbana, IL); Morales; Jose J. (Urbana, IL); Reid; Joel (Rochester, MN); Reymundo; Isabel (Madrid, ES); Floriano; Pablo (Madrid, ES); Gravalos; Lola Garcia (Madrid, ES)
Assignee: Pharma Mar, S.A. (Madrid, ES)
Appl. No.: 971852
Filed: October 3, 2001
Current U.S. Class: 568/584
Intern'l Class: C07C 205//00
Field of Search: 568/584 435/25 514/250 544/233 546/38