Streptenols F-I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023.

PharmaMar I+D .




Journal of Natural Products .




Copyright © 2017 The American Chemical Society and American Society of Pharmacognosy . Publication Date (Web): February 23, 2017 .

Tarazona G, Schleissner C, Rodríguez P, Pérez M, Cañedo LM, Cuevas C.

Author information : Research & Development Department, PharmaMar S. A. , Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770, Colmenar Viejo, Madrid, Spain.

Abstract :

A Marine-Derived Bacterium, Streptomyces Misionensis BAT-10-03-123, has produced four new streptenol derivatives, F, G, H, and I (1-4), as well as the known streptenols A and C (5 and 6).

Their planar structures were elucidated by detailed analysis of spectroscopic data. 

The absolute configurations of the new streptenol compounds were determined by chemical and spectroscopic methods, including Mosher's ester method. 

All of the compounds were tested for cytotoxicity against four selected cancer cell lines.
PMID: 28230357 DOI: 10.1021/acs.jnatprod.6b01057