07 junio 2018

Njaoamine I . A Cytotoxic Polycyclic Alkaloid from the Haplosclerida Sponge Haliclona (Reniera) sp. .

Author links open overlay panel Carlos Urda / Carmen Cuevas .

• A New Alkaloid was Isolated from a Sponge of Haliclona (Reniera) sp Genus.

• It’s characterized by a Tricyclic Nitrogenated, one of them bearing a Quinoline.

• It Displays Cytotoxic Activity against Human Tumor Cell Lines in Micromolar Range.

Abstract :

A new cytotoxic polycyclic alkaloid containing a quinoline moiety, njaoamine I (1) has been isolated from the methanol extract of the sponge Haliclona (Reniera) sp. collected at Okuza Island, Tanzania. The structure of compound 1 was determined by 1D and 2D NMR and HRMS data analysis. Its relative configuration was elucidated by a NOESY experiment and confirmed by comparison of its NMR spectral data to those of njaoamines A–H. Moreover, njaoamine G (2) was also detected by LC/MS analysis of the methanol extract. Njaoamine I (1) displays cytotoxic activity against a panel of three human tumor cell lines in the micromolar range.