Yondelis , Resultados en Cancer de Mama . A Diverse Induction of Apoptosis by Trabectedin in MCF-7 (HER2−/ER+) and MDA-MB-453 (HER2+/ER−) Breast Cancer Cells .

*.- Breast cancer cells are more sensitive to Trabectedin as compared to MCF-10A cells.

*.- Trabectedin induces apoptotic cell death in MCF-7 and MDA-MB-453 breast cancer cells.

*.- Trabectedin activates the death receptor mediated apoptotic pathway in MCF-7 cells.

*.- Trabectedin activates the mitochondria mediated apoptotic pathway in MDA-MB-453 cells.

*.- Trabectedin induces reactive oxygen species generation in both breast cancer cells.

*.- We have shown that trabectedin causes selective activation of extrinsic and intrinsic apoptotic pathways in two genotypically different breast cancer cells.

*- This preliminary data might guide clinicians to choose appropriate combination agents with trabectedin based on different molecular subtypes of breast cancer.


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