Yondelis Ovario UK . Cost-Effectiveness of Trabectedin Plus Pegylated Liposomal Doxorubicin for the Treatment of Women with Relapsed Platinum-Sensitive Ovarian Cancer in the UK: Analysis Based on the Final Survival Data of the OVA-301 Trial.

... Results


Over a lifetime horizon, trabectedin plus PLD increased mean progression-free survival by 3.0 months and overall survival by 9.7 months compared with PLD alone. The additional cost and QALYs of trabectedin plus PLD were £18,476 and 0.49, resulting in an incremental cost-effectiveness ratio of £38,026 per QALY. Sensitivity analyses showed that results were sensitive to platinum-free interval adjustment and the choice of survival distributions.

Conclusions

The analysis estimated a significant improvement in mean overall survival and incremental cost per QALY compared with that calculated in the original National Institute for Health and Clinical Excellence assessment, which was based on immature survival data.

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