Barcelona, 18 may (EFE).- La empresa biotecnológica catalana Oryzon Genómics, centrada en la epigenética para desarrollar terapias en oncología y enfermedades neurodegenerativas, ha recibido una subvención de 270.000 dólares de la Fundación para el Descubrimiento de la Cura contra el Alzheimer de EEUU (ADDF).
La subvención es para que la empresa desarrolle y ensaye la molécula ORY-2001, un inhibidor doble LSD1-MAOB, que es un nuevo enfoque terapéutico para la enfermedad de Alzheimer.
Según ha informado la compañía en un comunicado, el premio ADDF servirá para financiar la caracterización toxicológica preclínica necesaria para llevar a ensayo clínico la molécula ORY-2001.
La molécula de Oryzon se dirige a la enzima LSD1, una histona demetilasa que regula la expresión de importantes genes que las neuronas necesitan para mantenerse con vida.
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18 mayo 2015
GRECIA / CE . Principio de acuerdo según prensa
La Comisión Europea (CE) presentó hoy a los demás integrantes de las negociaciones con Grecia un acuerdo de compromiso que contempla un desembolso parcial del rescate en junio y un pacto global en otoño, según informaciones del rotativo heleno "To Vima". El documento, filtrado en exclusiva por este diario, exige a Grecia aprobar un paquete de medidas por un total de 5.000 millones de euros para cubrir la brecha financiera prevista para éste y el próximo año. Para lograr esta cuantía, Grecia deberá, entre otras medidas, reformar el sistema actual del impuesto sobre el valor añadido (IVA) y sustituir los tres tipos vigentes (23 %, 13% y 6,5%) por dos, uno del 18%, que se limitaría al 15% en los pagos con tarjeta, y uno reducido del 5%.
Yondelis . Meningiomas are the most common intracranial tumors .
Antiangiogenic Treatment of Meningiomas .
This article is part of the Topical Collection on Neuro-oncology // 15 May 2015 .
Matthias Preusser MD, Christine Marosi MD
Opinion statement
Meningiomas are the most common intracranial tumors and the majority of cases is curable by surgical resection.
Incompletely resected tumors and tumors with signs of increased malignancy (WHO grade II and III tumors) are prone to recur. In meningiomas relapsing after surgical resection and after exhaustion of radiotherapeutic options, drug therapy is to be considered.
A variety of drugs has been studied in meningiomas, including hydroxyurea, temozolomide, irinotecan, interferon-alpha, mifepristone, octreotide analogues, megestrol acetate, bevacizumab, sunitinib, vatalinib, imatinib, erlotinib, and gefitinib.
Unfortunately, most of these agents have shown no or very limited activity against meningiomas and cannot be recommended for clinical use. Compounds with antiangiogenic properties, i.e., bevacizumab, sunitinib, and vatalinib have shown potential efficacy in uncontrolled studies and should be investigated further, ideally in randomized clinical trials.
Emerging clinical studies will evaluate novel medical treatment approaches including the tetra-hydroisoquinoline alkaloid Yondelis (European Organisation for Research and Treatment of Cancer (EORTC) phase II trial 1320) and SMO or AKT inhibitors in molecularly selected cases.
This article is part of the Topical Collection on Neuro-oncology // 15 May 2015 .
Matthias Preusser MD, Christine Marosi MD
Opinion statement
Meningiomas are the most common intracranial tumors and the majority of cases is curable by surgical resection.
Incompletely resected tumors and tumors with signs of increased malignancy (WHO grade II and III tumors) are prone to recur. In meningiomas relapsing after surgical resection and after exhaustion of radiotherapeutic options, drug therapy is to be considered.
A variety of drugs has been studied in meningiomas, including hydroxyurea, temozolomide, irinotecan, interferon-alpha, mifepristone, octreotide analogues, megestrol acetate, bevacizumab, sunitinib, vatalinib, imatinib, erlotinib, and gefitinib.
Unfortunately, most of these agents have shown no or very limited activity against meningiomas and cannot be recommended for clinical use. Compounds with antiangiogenic properties, i.e., bevacizumab, sunitinib, and vatalinib have shown potential efficacy in uncontrolled studies and should be investigated further, ideally in randomized clinical trials.
Emerging clinical studies will evaluate novel medical treatment approaches including the tetra-hydroisoquinoline alkaloid Yondelis (European Organisation for Research and Treatment of Cancer (EORTC) phase II trial 1320) and SMO or AKT inhibitors in molecularly selected cases.
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