NeuroPharma , su Primer Farmaco demuestra Potencial Terapeutico Alzheimer .

2007 May 23

NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.
Luna-Medina R, Cortes-Canteli M, Sanchez-Galiano S, Morales-Garcia JA, Martinez A, Santos A, Perez-Castillo A .

Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 28029 Madrid, Spain.
Inflammation and neurodegeneration coexist in many acute damage and chronic CNS disorders (e.g., stroke, Alzheimer's disease, Parkinson's disease). A well characterized animal model of brain damage involves administration of kainic acid, which causes limbic seizure activity and subsequent neuronal death, especially in the CA1 and CA3 pyramidal cells and interneurons in the hilus of the hippocampus. Our previous work demonstrated a potent anti-inflammatory and neuroprotective effect of two thiadiazolidinones compounds, NP00111 (2,4-dibenzyl-[1,2,4]thiadiazolidine-3,5-dione) and NP01138 (2-ethyl-4-phenyl-[1,2,4]thiadiazolidine-3,5-dione), in primary cultures of cortical neurons, astrocytes, and microglia. Here, we show that injection of NP031112, a more potent thiadiazolidinone derivative, into the rat hippocampus dramatically reduces kainic acid-induced inflammation, as measured by edema formation using T2-weighted magnetic resonance imaging and glial activation and has a neuroprotective effect in the damaged areas of the hippocampus. Last, NP031112-induced neuroprotection, both in vitro and in vivo, was substantially attenuated by cotreatment with GW9662 (2-chloro-5-nitrobenzanilide), a known antagonist of the nuclear receptor peroxisome proliferator-activated receptor gamma, suggesting that the effects of NP031112 can be mediated through activation of this receptor. As such, these findings identify NP031112 as a potential therapeutic agent for the treatment of neurodegenerative disorders.

Zeltia , presentacion en la Bolsa de madrid 30/5/2007 .

De momento la ruta para verlo es ir a www.cnmv.es y buscar por "" entidades "" a Zeltia y alli mirar en "" Otras comunicaciones "" .

*.- Capitalizacion 1,4 Billones e.
*.- Free Float ...menos del 50 % o sea unos 100.000 Millones de acciones a descontar aun las tuyas y las mias .
*.- 7ª Empresa Española en I+D .
*.-Yondelis Sarcoma : Protocolo especial de Evaluacion "" Acordado "" con la FDA y Diseño del estudio ""Aceptado "" segun directrices de la EMEA . Espera su aprobación para Julio o Agosto 2007 .
*.- Yondelis / Doxil antes del 30 de Junio se cierra el estudio y ya no acepta mas Pacientes ( Se esperaba cerrarlo para Octubre ) ......Registro FDA - EMEA en 2008 . El Comite Independiente de Monitorizacion de Datos dio el OK y recomendo la continuacion del Estudio sin modificar ni una sola coma .
*.- Mercado Global del Cancer es de 14 Bn en el 2005 y se espera que crezca hasta los 31 Bn en 2010 .
*.- Ventas del Doxil en Ovario en 2005 = 303 $$ M.
Ventas del Doxil para 2006 = 346 $$ M .
VEntas del Doxil para 2011 = 495 $$ M .segun estimaciones .
*.- Zeltia entraria en beneficios tras el lanzamiento de la Segunada Indicacion del Yondelis ( Ovario ).
*.-Precio del tratamiento con Yondelis rondaria los 20.000 euros ....unos 3.350.000 de las antiguas pesetas .

Neuropharma, filial de Zeltia, prevé salir a bolsa a finales de 2008 .

El 80% de los pacientes con cáncer de pulmón tarda cinco años o menos en morir .