13 diciembre 2016

PM01183 / PM1183 / Lurbinectedin / Trytamicidin .

Resultado de imagen de ecteinascidiaLatest Information Update: 09 Dec 2016.

Price : $50 .


At a glance 

         OriginatorPharmaMar .

  •            DeveloperFundacion Instituto Valenciano de                                            Oncologia; PharmaMar .


  • Class3-ring heterocyclic compounds; Acetates; Alkaloids; Antineoplastics; Dioxolanes; Indoles; Small molecules


  • Mechanism of ActionAlkylating agents; Apoptosis stimulants; Cell cycle inhibitors


  • Orphan Drug StatusYes - Ovarian cancer



  • On Fast trackNo


  • New Molecular EntityYes


Highest Development Phases

                Phase IIIOvarian cancer; Small cell lung cancer. 

  • Phase IIBreast cancer; Non-small cell lung cancer; Pancreatic cancer; Sarcoma; Solid tumours.


  • Phase ILeukaemia .

Most Recent Events

  • 28 Nov 2016Phase-I clinical trials in Solid tumours (Inoperable/Unresectable, Late-stage disease) in Japan (IV).


  • 18 Oct 2016PharmaMar completes enrolment in the Phase-III CORAIL trial for Ovarian Cancer (Second-line therapy or greater) in USA (IV) .


  • 10 Oct 2016Efficacy data from a phase II trial in Breast cancer presented at the 41st European Society for Medical Oncology Congress (ESMO-2016) .