29 junio 2007
28 junio 2007
27 junio 2007
26 junio 2007
Pharma Mar consigue la Patente de una Nueva Familia de AntiCancerigenos derivados de la Esponga Theonella Swinhoei .
ANTITUMOUR COMPOUNDS .
Publication number: WO2007068776
Publication date: 2007-06-21
Inventor: MARTIN LOPEZ MA JESUS (ES); REYES BENITEZ JOSE FERNANDO (ES); FERNANDEZ RODRIGUEZ ROGELIO (ES); FRANCESCH SOLLOSO ANDRES (ES); CUEVAS MARCHANTE MARIA DEL CAR (ES); COELLO MOLINERO LAURA (ES)
Applicant: PHARMA MAR SA (ES); MARTIN LOPEZ MA JESUS (ES); REYES BENITEZ JOSE FERNANDO (ES); FERNANDEZ RODRIGUEZ ROGELIO (ES); FRANCESCH SOLLOSO ANDRES (ES); CUEVAS MARCHANTE MARIA DEL CAR (ES); COELLO MOLINERO LAURA
(ES) Classification: - international: C07D493/18; A61K31/357; A61P35/00; C07D311/00; C07D323/00; C07D493/22; C07D493/00; A61K31/357; A61P35/00; C07D311/00; C07D323/00; - European: Application number: WO2006ES00687 20061214 Priority number(s): ES20050003092 20051215
Abstract of WO2007068776 The invention relates to novel antitumour compounds having general formula (I) and to the corresponding pharmaceutically-acceptable salts, derivatives, pro-drugs and stereoisomers thereof. The inventive compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. Said compounds have a cytotoxic activity and can be used for the treatment of cancer.
Abstract of WO2007068776 The invention relates to novel antitumour compounds having general formula (I) and to the corresponding pharmaceutically-acceptable salts, derivatives, pro-drugs and stereoisomers thereof. The inventive compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. Said compounds have a cytotoxic activity and can be used for the treatment of cancer.
25 junio 2007
New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid.
Junio 2007 .
New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid.
Miguel Del Corral JM, Castro MA, Lucena Rodrı Guez M, Chamorro P, Cuevas C, San Feliciano A
Departamento de Quı´mica Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain.
Diterpenylquinone/hydroquinone derivatives were prepared through Diels-Alder cycloaddition between natural myrcecommunic acid or its methyl ester and p-benzoquinone (p-BQ), using BF(3).Et(2)O as catalyst or under microwave (Mw) irradiation. Acetyl, methyl and benzyl derivatives of several diterpenylnaphthohydroquinone were prepared from cycloadducts following two basic synthetic strategies, either protection before aromatisation or viceversa. Some of them were further functionalised at the B-ring of the decaline core. Most of the new compounds were evaluated and some of them resulted cytotoxic against several tumour cell lines with IC(50) values under the muM level.
New cytotoxic diterpenylnaphthohydroquinone derivatives obtained from a natural diterpenoid.
Miguel Del Corral JM, Castro MA, Lucena Rodrı Guez M, Chamorro P, Cuevas C, San Feliciano A
Departamento de Quı´mica Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain.
Diterpenylquinone/hydroquinone derivatives were prepared through Diels-Alder cycloaddition between natural myrcecommunic acid or its methyl ester and p-benzoquinone (p-BQ), using BF(3).Et(2)O as catalyst or under microwave (Mw) irradiation. Acetyl, methyl and benzyl derivatives of several diterpenylnaphthohydroquinone were prepared from cycloadducts following two basic synthetic strategies, either protection before aromatisation or viceversa. Some of them were further functionalised at the B-ring of the decaline core. Most of the new compounds were evaluated and some of them resulted cytotoxic against several tumour cell lines with IC(50) values under the muM level.
23 junio 2007
22 junio 2007
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