EL ENSAYO TREASURE DEMUESTRA QUE AÑADIR RADIOTERAPIA TORÁCICA AL TRATAMIENTO DE MANTENIMIENTO CON ATEZOLIZUMAB EN EL SMALL CELL LUNG CANCER EXTENSIVE-STAGE ( SCLC-ES ) AUMENTA LA TOXICIDAD MORTAL SIN MEJORAR LA SUPERVIVENCIA .

IN SCLC-ES, RADIOTHERAPY PLUS ATEZOLIZUMAB UPS FATAL EVENTS . 23 JULY 2026 .

EN  SMALL CELL LUNG CANCER EXTENSIVE-STAGE ( SCLC-ES ) , LA RADIOTERAPIA COMBINADA CON ATEZOLIZUMAB AUMENTA LOS EVENTOS FATALES .

THORACIC RADIOTHERAPY ADDED TO ATEZOLIZUMAB RAISED TOXICITY 

IN SMALL CELL LUNG CANCER .

Key Takeaways :

*.- Early termination after 68 randomizations reflected a 61% serious AE rate and 19% treatment-related deaths with radiotherapy, versus 18% and 3% on ATEZOLIZUMAB Alone .

*.- Overall Survival numerically worsened with consolidative thoracic radiotherapy (median 6.7 vs 13.4 months; 1-year OS 30% vs 57%), despite no PFS improvement .

*.- Infections and respiratory toxicities, including pneumonitis, predominated among serious events in the radiotherapy arm, suggesting additive pulmonary and immunologic injury during maintenance ATEZOLIZUMAB .

*.- Radiotherapy induced pronounced, persistent lymphocyte depletion without parallel Neutropenia, supporting a mechanism of immunosuppression-driven infection risk; lower baseline DLCO may identify particularly vulnerable patients .

*.- Concordant safety concerns from PACIFIC-2 and CheckMate 73L reinforce that combining thoracic irradiation with checkpoint blockade warrants refined dose constraints, timing strategies, and prospective stopping rules .

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