Masashi Yokoya, Ryoko Toyoshima, Toshihiro Suzuki, Vy H. Le, Robert M. Williams, and Naoki Saito .J. Org. Chem., Just Accepted Manuscript.
DOI: 10.1021/acs.joc.6b00327 .
Publication Date (Web): March 28, 2016 .
Abstract
A stereoselective total synthesis of (−)-Renieramycin T (1t) from a key tetrahydroisoquinoline intermediate previously utilized in our formal total synthesis of Ecteinascidin 743 is described. The synthesis features a concise approach for construction of the pentacyclic framework using a Pictet-Spengler cyclization of bromo-substituted carbinolamine 17, which overcomes the previous regioselectivity problem. The results of cytotoxicity studies are also presented.
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