La incorporacion de nuevas moleculas es continua .....como lo son las expediciones .
En PharmaMar la fase de descubrimientos , que cubre la recoleccion , fermentacion , taxonomia , screening ......patentes es super activa ...son ya mas de 600 las patentes conseguidas y mas de 700 las pendientes ya solicitadas ......Blanes versus Antartida .
Acerolide, a new cytotoxic cembranolide from the soft coral Pseudopterogorgia acerosa.
Montalvo D, Amade P, Funel-Le Bon C, Fernandez R, Reyes F.
Medicinal Chemistry Department, PharmaMar S.A., Pol. Ind. La Mina Norte. Avda. de los Reyes 1. 28770 (Colmenar Viejo) Madrid, Spain.
A new cembranolide, acerolide (1) together with the known compound pseudopterolide (2) were isolated from the 2-propanol extract of the soft coral Pseudopterogorgia acerosa. The structure of 1 was determined on the basis of detailed spectroscopic analysis. Compound 1 showed moderate in vitro cytotoxicity against a panel of 14 tumor cell lines.
*********************************************************
2006 Jul 12
New cytotoxic furoquinones obtained from terpenyl-1,4-naphthoquinones and 1,4-anthracenediones.
Miguel Del Corral JM, Castro MA, Oliveira AB, Gualberto SA, Cuevas C, Feliciano AS
Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, E-37007 Salamanca, Spain.
A series of new furoterpenyl-1,4-naphtho(anthra)quinones have been prepared via oxidative cyclization of the corresponding 2-hydroxy-3-butenyl-1,4-naphtho(anthra)quinones. Depending on the reaction conditions the 1,2-quinones or the 1,4-quinones were obtained. Several new furo-1,4-anthraquinones were also obtained by condensation of 2,3-dichloroquinones with 1,3-dicarbonyls. The compounds synthesized have been evaluated for their cytotoxicity against neoplastic cell lines, some of them being effective below the micromolar level.
Graphical abstract
Several new cytotoxic furoterpenyl-1,4-naphtho(anthra)quinones and furoterpenyl-1,2-naphtho(anthra)quinones have been prepared via oxidative cyclization from the corresponding 1,4-naphtho(anthra)quinones.
Keywords: Terpenylnaphthoquinones; 1,4-Anthracenediones; Furo-1,2-quinones; Furo-1,4-quinones; Cytotoxicity