Study Presents Association Between High Cholesterol and Breast Cancer
Analysis of over 1 million British women over 14 years highlights a strong association between high blood cholesterol and breast cancer.
High cholesterol is damaging to health. A new study led by Dr. Rahul Potluri, founder of the ACALM Study Unit, claims high cholesterol levels fuel the growth of breast cancer, reports Medicalxpress.
Dr Potluri said: "Our preliminary study suggests that women with high cholesterol in their blood may be at greater risk of getting breast cancer. It raises the possibility of preventing breast cancer with statins, which lower cholesterol, but as this is a primitive study, significant time and research is needed before this idea can be tested."
Studies conducted in the past have highlighted a link between obesity and breast cancer. An animal study showed that reducing circulation of cholesterol in mice or by altering the metabolism, they could prevent or treat breast cancer. In this study the researchers investigated whether there existed any association between hyperlipidaemia (high cholesterol) and breast cancer.
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04 julio 2014
MEF2 . Researchers Discover a “Switch” in Alzheimer’s and Stroke Patient Brains That Prevents the Generation and Survival of Neurons .
Hallan el " Interruptor " que Mata las Neuronas en el Cerebro con Alzheimer .
Study finds a modification to the transcriptional protein MEF2 that inhibits the growth of new brain cells and survival of existing cells. The findings show promise for therapeutic intervention for a variety of neurodegenerative disorders.
Released: 7/3/2014 . Source Newsroom: Sanford-Burnham Medical Research Institute .
Newswise — La Jolla, Calif., July 3, 2014 .
A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical “switch” that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain. The switch that shuts off the signals that promote neuron production and survival is in abundance in the brains of Alzheimer’s patients and stroke victims. The study, published July 3 in Cell Reports, suggests that chemical switch, MEF2, may be a potential therapeutic target to protect against neuronal loss in a variety of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and autism.
“We have shown that when nitric oxide (NO)—a highly reactive free radical—reacts with MEF2, MEF2 can no longer bind to and activate the genes that drive neurogenesis and neuronal survival,” said Stuart Lipton, M.D., Ph.D., director and professor in the Neuroscience and Aging Research Center at Sanford-Burnham, and a practicing clinical neurologist. “What’s unique here is that a single alteration to MEF2 controls two distinct events—the generation of new neurons and the survival of existing neurons,” added Lipton, who is senior author of the study.
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Study finds a modification to the transcriptional protein MEF2 that inhibits the growth of new brain cells and survival of existing cells. The findings show promise for therapeutic intervention for a variety of neurodegenerative disorders.
Released: 7/3/2014 . Source Newsroom: Sanford-Burnham Medical Research Institute .
Newswise — La Jolla, Calif., July 3, 2014 .
A new study by researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) has identified a chemical “switch” that controls both the generation of new neurons from neural stem cells and the survival of existing nerve cells in the brain. The switch that shuts off the signals that promote neuron production and survival is in abundance in the brains of Alzheimer’s patients and stroke victims. The study, published July 3 in Cell Reports, suggests that chemical switch, MEF2, may be a potential therapeutic target to protect against neuronal loss in a variety of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s and autism.
“We have shown that when nitric oxide (NO)—a highly reactive free radical—reacts with MEF2, MEF2 can no longer bind to and activate the genes that drive neurogenesis and neuronal survival,” said Stuart Lipton, M.D., Ph.D., director and professor in the Neuroscience and Aging Research Center at Sanford-Burnham, and a practicing clinical neurologist. “What’s unique here is that a single alteration to MEF2 controls two distinct events—the generation of new neurons and the survival of existing neurons,” added Lipton, who is senior author of the study.
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