Cabozantinib (Cabometyx) demonstrated consistent improvement in progression-free survival (PFS) and overall survival (OS) over everolimus (Afinitor) and sunitinib (Sutent), irrespective of PD-L1 status, across two randomized controlled clinical trials in patients with metastatic clear cell renal cell carcinoma (mRCC).
In addition, using the patient populations from the METEOR and CABOSUN clinical trials, PD-L1 expression in tumor cells was found to be associated with shorter PFS and OS in both trials, reported Toni K. Choueiri, MD, at the 2018 European Society of Medical Oncology annual congress in Munich. ...