Appraising the Current Role of Chemotherapy for the Treatment of Sarcoma... Newer cytotoxic agents with an improved safety profile, such as trabectedin and palifosfamide, are currently in development. Future research needs to focus on identification of subpopulations of patients that are most likely to benefit from chemotherapy.
... More stringent patient selection, ie, establishment of hepatic function parameters, and concomitant steroid administration have largely eliminated this problem.
J&J EEUU : A randomized, phase III registration trial of trabectedin versus dacarbazine in patients with advanced leiomyosarcoma or liposarcoma is currently recruiting patients.
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