Una de estas Drogas podría ser el Yondelis según lo publicado por Cientificos Italianos :
Role of Macrophage Targeting in the Antitumor Activity of Trabectedin .
http://www.sciencedirect.com/science/journal/15356108/23/2
There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic agent, induces rapid apoptosis exclusively in mononuclear phagocytes. In four mouse tumor models, trabectedin caused selective depletion of monocytes/macrophages in blood, spleens, and tumors, with an associated reduction of angiogenesis. By using trabectedin-resistant tumor cells and myeloid cell transfer or depletion experiments, we demonstrate that cytotoxicity on mononuclear phagocytes is a key component of its antitumor activity. Monocyte depletion, including tumor-associated macrophages, was observed in treated tumor patients.
Trabectedin activates caspase-8-dependent apoptosis; selectivity for monocytes versus neutrophils and lymphocytes is due to differential expression of signaling and decoy TRAIL receptors.
This unexpected property may be exploited in different therapeutic strategies.
Copyright © 2013 Elsevier Inc. All rights reserved.
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La Nueva Propiedad del Yondelis recogida en la Prensa Italiana ... cada editorial con un analisis propio :
http://www.repubblica.it/salute/ricerca/2013/02/12/news/farmaco_cellule_corrotte-52477493/
http://scienze.befan.it/trabectedina-un-farmaco-anti-tumore-dai-molluschi-marini/
http://www.bolognatg24.it/top-news/2013/02/13/40652/un-mollusco-marino-la-nuova-arma-contro-il-cancro/
http://www.italiasalute.it/2779/h/La-trabectedina-aggredisce-tumore-e-i-suoi-alleati.html
http://www.campanianotizie.com/attualita/mondo/51189-tumori-dai-caraibi-farmaco-che-uccide-poliziotti-corrotti-cancro.html
http://www.ogginotizie.it/214887-tumori-un-farmaco-dai-molluschi-marini/
http://scienze.fanpage.it/i-nuovi-effetti-antitumorali-di-un-farmaco-ricavato-dal-mollusco-marino/
http://www.healthdesk.it/ricerca/articolo/5828/1360693406
http://www.policliniconews.it/schede.cfm?id=511&Un_nuovo_farmaco_pu%C3%B2_bloccare_le_cellule_tumorali
http://notizie.tiscali.it/articoli/scienza/13/02/mollusco-marino-nuovo-farmaco-contro-tumori.html