CAMBIO DE DISCURSO : LA SEGUNDA LINEA SMALL CELL LUNG CANCER EXTENSIVE-STAGE TRAS EL FIASCO DE LA FASE III LAGOON YA MEJOR NI NOMBRARLA ... CAMBIAMOS DISCURSO A MANTENIMIENTO EN PRIMERA LINEA Y PASAMOS DEL VIAL DE 4 Mg AI VIAL DE 2 Mg . ////. ESPERAMOS DECISIÓN DE JAZZPHARMA O BIEN LA DECISIÓN DE LA FDA TEMA SEGUNDA LÍNEA EEUU .////. 2 DE OCTUBRE DE 2028 ... ES LA FECHA MÁS TEPMPRANA PARA LA POSIBLE ENTRADA DE GENÉRICOS .
14 junio 2007
12 junio 2007
11 junio 2007
09 junio 2007
Cronista de un Cáncer . ( El Mundo ) .
Cronista de un cáncer
En noviembre de 2006, a Deborah Charles le diagnosticaron un cáncer de mama. Desde entonces, esta periodista de 41 años se ha sometido a tres operaciones y cuatro ciclos de quimioterapia. Un compañero de su agencia la ha acompañado durante una semana. (Fotos: Jim Bourg REUTERS) .
En noviembre de 2006, a Deborah Charles le diagnosticaron un cáncer de mama. Desde entonces, esta periodista de 41 años se ha sometido a tres operaciones y cuatro ciclos de quimioterapia. Un compañero de su agencia la ha acompañado durante una semana. (Fotos: Jim Bourg REUTERS) .
08 junio 2007
07 junio 2007
Yondelis ( ET-743 ) , evidence of activity in advanced, pretreated soft tissue and bone sarcoma patients.
Huygh G, Clement PM, Dumez H, Schöffski P, Wildiers H, Selleslach J, Jimeno JM, Wever ID, Sciot R, Duck L, Van Oosterom AT.
2006 Dec 31.
Leuven Cancer Institute, Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Purpose. To evaluate the activity and safety of ecteinascidin (ET-743) in pretreated patients with advanced or metastatic soft tissue and bone sarcoma. Patients or subjects. Eighty-nine patients received ET-743 as a 24-hour continuous infusion at a dose of 900-1500 mug/m(2) every 3 weeks. Results. We observed one complete remission, 5 partial remissions, one minimal response, and 16 patients with a disease stabilization of 6 months or more. The objective response rate was 6.7% and the clinical benefit rate at 3 and 6 months was 37.7% and 23.4%, respectively. Responses were noted in patients with lipo-, leiomyo-, osteo-, and myogenic sarcoma, with a median duration of 9.85 months. Toxicity mainly involved an asymptomatic elevation of transaminases and neutropenia. Estimated 1- and 2-year survival rates were 39.4% and 15.8%. Median overall survival was 8.25 months. Discussion. This retrospective analysis confirms that ET-743 induces objective responses and progression arrest in a clinically relevant proportion of patients.
2006 Dec 31.
Leuven Cancer Institute, Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium.
Purpose. To evaluate the activity and safety of ecteinascidin (ET-743) in pretreated patients with advanced or metastatic soft tissue and bone sarcoma. Patients or subjects. Eighty-nine patients received ET-743 as a 24-hour continuous infusion at a dose of 900-1500 mug/m(2) every 3 weeks. Results. We observed one complete remission, 5 partial remissions, one minimal response, and 16 patients with a disease stabilization of 6 months or more. The objective response rate was 6.7% and the clinical benefit rate at 3 and 6 months was 37.7% and 23.4%, respectively. Responses were noted in patients with lipo-, leiomyo-, osteo-, and myogenic sarcoma, with a median duration of 9.85 months. Toxicity mainly involved an asymptomatic elevation of transaminases and neutropenia. Estimated 1- and 2-year survival rates were 39.4% and 15.8%. Median overall survival was 8.25 months. Discussion. This retrospective analysis confirms that ET-743 induces objective responses and progression arrest in a clinically relevant proportion of patients.
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