Ecteinascidin 743 . Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line .

... This hybrid system and precursor are distinct from the previously described universal modes involving the NRPS machinery. They exemplify an alternate strategy in hybrid NRPS biochemistry and enrich the diversity of precursors for NRPS combinatorial biosynthesis.

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