IMFORTE ( LURBINECTEDIN / ATEZOLIZUMAB ) ... . Understanding “ Paradigm-Changing ” Events in Small Cell Lung Cancer Care . The Frontline Treatment Algorithm in SCLC is Poised To Look “ Radically Different ” in The Upcoming Years, According To Anne Chiang, MD, PhD .


CANCERNETWORK. 25 SEPTEMBER 2025 .


There Is a Lot Of Excitement Surrounding The Use of Different Immunotherapies In The Frontline Management Of SMALL CELL LUNG CANCER ( SCLC ), And Various data Bring “ Terrific News ” For The MAINTENANCE Setting And Other PHASES Of Treatment, According To Anne Chiang, MD, PhD. . 

CancerNetwork® Spoke With Chiang To further Understand The Current Treatment Landscape for Patients With SCLC . ...


CANCERNETWORK : What Do Current Treatment Options Look Like In The Management Of SCLC ? What Factors Do You Consider When Sequencing Different Therapies For Patients ? .


This Is An Area That We Need To Focus On Because It's Going To Be Changing In The Near Future .There's a Lot Of Excitement Around That. For Frontline [ Therapy ], Right Now, We Still Stick With Our 2 Trials .

That's Either The IMpower133 [ NCT02763579 ] Régimen — CARBOPLATIN And ETOPÓSIDE With ATEZOLIZUMAB [ TECENTRIQ ] —Or The CASPIAN Trial [NCT03043872]— CARBOPLATIN / ETOPÓSIDE or CISPLATIN / ETOPÓSIDE Plus DURVALUMAB [ IMFINZI ] Followed By MAINTENANCE DURVALUMAB . 


The Exciting Part Is That At The 2025 AMÉRICAN SOCIETY OF CLINICAL ONCOLOGY [ ASCO ] ANUAL MEETING, [ Findings From ] The PHASE III IMforte Trial [ NCT05091567 ] Were Read Out .

That's a MAINTENANCE Trial Adding LURBINECTEDIN [ ZEPZELCA ] To MAINTENANCE ATEZOLIZUMAB .

That Showed a Positive OVERALL SURVIVAL Benefit Of 3 MONTHS .

It Was Conducted In Patients Who Did Not Have Brain Metastases, But For Those Patients Who Were Fit After Induction Therapy, We Have Been Talking To Them About Doing Switch MAINTENANCE With LURBINECTEDIN Plus ATEZOLIZUMAB . ...