Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is a multistep process that involves the infection of angiotensin-converting enzyme 2 (ACE2)-expressing lung epithelial cells followed by uncontrolled viral replication, which leads to cell lysis and the release of damage-associated molecular patterns (DAMPs) .When the neighboring cells recognize these molecules, they produce a pro-inflammatory environment by releasing cytokines such as Interleukin 6 (IL-6) and Interleukin-10 (IL-10), which recruit and activate macrophages, monocytes, and T cells (also called T lymphocytes) . ...
