AUGUST 18, 2016 /// Ines Martins, PhDBY INES MARTINS, PHD IN NEWS.... The drug works through two distinct mechanisms. First, it binds to the DNA and prevents DNA-repair mechanisms, blocks the expression of several tumor-promoting genes (oncogenes) and factors that induce drug resistance. Then, it interacts with cells from the tumor microenvironment, particularly macrophages, preventing their pro-tumoral activity.
...