02 julio 2014

Third-line Trabectedin for a Metastatic Desmoplastic Small Round Cell Tumour Treated with Multimodal Therapy.

Anticancer Res. 2014 Jul .

Brunetti AE , Delcuratolo S , Lorusso V , Palermo L , DI Giorgio A , Pisconti S , Silvestris N .

Abstract
Background:

Desmoplastic small round cell tumour (DSRCT) is a rare and aggressive cancer that usually develops in the peritoneal cavity of young males.

Its prognosis is dismal, with current treatment options including the combination of multi-agent chemotherapy, aggressive surgery, radiation therapy, and autologous stem cell transplantation.

Hyperthermic intraperitoneal chemotherapy (HIPEC) may also be an option.

Case Report:

Herein we report the administration of the marine-derived multi-target antineoplastic agent, trabectedin, in a patient with DSRCT, heavily pre-treated with conventional multi-agent chemotherapy, HIPEC, and surgery.

Results:

The patient achieved a prolonged partial response and an extended period of stable disease with third-line trabectedin, following disease progression after conventional multi-agent chemotherapy, HIPEC, and surgery. Conclusion: Trabectedin may be a treatment option in multimodal therapy for the management of DSRCT and warrants further research to explore the impact of trabectedin in the treatment of this disease.