Multicenter, Randomized, Non-comparative, Open-label Phase II Trial on the Efficacy and Safety of the Combination of Bevacizumab and Trabectedin With or Without Carboplatin in Adult Women With Platinum Partially Sensitive Recurring Ovarian Cancer.
Recruitment Information :
Status : Recruiting
Start date : 2013-07
Last follow-up date : 2015-04 (Anticipated)
Primary completion date : 2014-03 (Anticipated)
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Administrative Data :
Organization name : Mario Negri Institute for Pharmacological Research
Organization study : ID IRFMN-OVA-6152
Sponsor : Mario Negri Institute for Pharmacological Research
Collaborator : PharmaMar
Collaborator : Hoffmann-La Roche
Health Authority Italy : The Italian Medicines Agency
Health Authority Italy : Ethics Committee
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Case Report :
Complete remission of recurrent ovarian clear cell carcinoma by chemotherapy with bevacizumab, trabectedin and oxaliplatin .
Abstract
Clear cell carcinoma of the ovary has shown an exceedingly chemo-resistant phenotype, especially in cases that are recurrent or refractory to previous therapy. Also, progression-free survival was less than 6 months, even in the patients that achieved response when they were treated with conventional anti-cancer cytotoxic agents. We present a case with recurrent and refractory ovarian clear cell carcinoma that achieved complete remission using a combination of bevacizumab, trabectedin and oxaliplatin. The progression-free interval of the patient is over 30 months, and she is still receiving the combination therapy without toxicities of more than grade 2.