Mechanism of action(MoA)
Tetrahydroisoquinoline alkaloid derived from the Caribbean marine tunicate, Ecteinascidia turbinata (now synthetically produced) [1]. Interacts with the minor groove of DNA and alkylates guanine at the N2 position, thus affecting various transcription factors involved in cell proliferation and the transcription-coupled nucleotide excision repair system. Blocks the cell cycle at the G2 phase. Also inhibits overexpression of multidrug resistance-1 gene (MDR-1). In preclinical models, active against different tumor types [2]. Active against melanoma in a human xenograft model [3] ...
Author(s)
The MMMP Team
Updated: Wednesday, January 7, 2009 07:29 PM