Use of Collismycin and Derivatives Thereof as Oxidative Stress Inhibitors .
Publication number: US2008275088 (A1)
Publication date: 2008-11-06
Inventor(s): MARTINEZ GIL ANA [ES]; EGEA PAOLA USAN [ES]; MEDINA PADILLA MIGUEL [ES]; PALOMERO ESTHER GARCIA [ES]; PEREZ BAZ JULIA [ES]; FERNANDEZ CHIMENO ROSA ISABEL [ES]; MEDARDE FERNANDEZ ANTONIO [ES]; CANEDO HERNANDEZ LIBRADA MARIA [ES]; ROMERO MILLAN FRANCISCO [ES]; CASTRO MORERA ANA [ES]; ALONSO CASCON MERCEDES [ES]; SANCHEZ QUESADA JORGE [ES]
Applicant(s): NEUROPHARMA S A [ES]; INST BIOMAR SA [ES]
Classification:
- international: A61K31/444; A61P3/10; A61P25/00; A61P25/16; A61P25/28; A61P29/00; C07D401/04; A61K31/4427; A61P3/00; A61P25/00; A61P29/00; C07D401/00
- European: A61K31/44
Application number: US20060996966 20060728
Priority number(s): EP20050380175 20050729; WO2006EP07521 20060728
Abstract of US 2008275088 (A1)
The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.
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La presente invención se refiere a la utilización de Collismycin y sus derivados como inhibidores del estrés oxidativo en las células y su utilización para la preparación de medicamentos para el tratamiento y / o prevención del estrés oxidativo inducido por enfermedades o condiciones, especialmente las enfermedades neurodegenerativas, tales como la enfermedad de Alzheimer La enfermedad y la enfermedad de Parkinson.