Es muy importante el tener en cuenta que las ventas del Yondelis estan basadas en la media de los tratamientos AntiCancerigenos que son de 5 ciclos .....mas ciclos equivale a toxicidad extrema del farmaco ....pero el Yondelis al no acumular toxicidad se puede continuar administrando ....con lo que tanto los pacientes ....como Zeltia ....como los accionistas .... saldrian beneficiados .
aqui tenemos un ejemplo de un paciente con 8 ciclos ya en el cuerpo y esta mas satisfecho que con el tratamiento de Priemra Linea ( Ifosamide / Doxorrubicin ) ....
........ahora direis que la primera linea era Ifosfamida y Antraciclinas ..... pues eso que Doxorrubicin es una Antraciclina ....quizas por eso J&J no tenga ninguna prisa ni ganas en lanzar Yondelis en Sarcoma en EEUU ...... o a lo mejor esta a la espera de combinarlo con su Doxo ????
Señora que expone la experiencia de su marido con el Yondelis en Inglaterra :
My husband XXX has had 8 cycles of yondelis for soft tissue sarcoma. The side effects have been minimal as compared to ifosamide/doxirubicin. He has 24 hours every 3 weeks thru a hickman line. The only real problem XXX has had is being admitted into hospital for 16 days because the line became infected and pneumonia set in. On a positive note, there has been a significant reduction in the size of tumours and up to press XXX has still got the Kidney that was scheduled for removal.
XXX has fatigue, shaking hands, (controlled) nausea. Drugs such as steroids, anti sickness etc sort him out though.
We are based in Lancashire, England and had to pay privately in order to get yondelis as it is unlicensed over here. Best ting we ever did!!!
Good luck and all the best. - England.