Vista . New potential immunotherapy target in pancreatic cancer identified .
Researchers have identified a new potential immunotherapy target in pancreatic cancer, which so far has been notoriously resistant to treatment with immune checkpoint blockade drugs effective against a variety of other cancers.
The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that infiltrated pancreatic tumors. Their paper will be published online Friday at the Proceedings of the National Academy of Sciences.
"VISTA is a potential therapeutic target in pancreatic cancer, and there are several antibodies to block VISTA under clinical development," said co-senior author Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology. "Additional research also needs to be done to see if we can come up with other targets for these VISTA-positive cells as well." ...
The University of Texas MD Anderson Cancer Center research team found overexpression of the immune checkpoint VISTA on immune cells, especially macrophages, that infiltrated pancreatic tumors. Their paper will be published online Friday at the Proceedings of the National Academy of Sciences.
"VISTA is a potential therapeutic target in pancreatic cancer, and there are several antibodies to block VISTA under clinical development," said co-senior author Padmanee Sharma, M.D., Ph.D., professor of Genitourinary Medical Oncology and Immunology. "Additional research also needs to be done to see if we can come up with other targets for these VISTA-positive cells as well." ...
Logran detener la metástasis del cáncer de mama con viejos antibióticos y otros fármacos conocidos . Post by Celtia .
Impedir la formación de metástasis es uno de los mayores retos a la hora de asegurar la supervivencia de los enfermos de cáncer. Algunas células que forman el tumor pueden desprenderse y viajar en grupos por la sangre. Así llegan a otros órganos del cuerpo y diseminan la enfermedad que antes estaba localizada en un solo lugar. Esto supone una vuelta a empezar en los tratamientos y una reducción de la supervivencia. Detectar estas células que se trasladan es muy difícil porque son muy pocas y nunca se tiene la certeza de que aunque existan, no aparezcan en los análisis porque hayan pasado desapercibidas.
Ahora, un equipo de científicos de la Universidad de Basilea (Suiza) ha encontrado una forma de separar entre sí las células tumorales que circulan por la sangre en grupos e impedir que formen metástasis. Lo que han visto es que, cuando estas células viajeras están agregadas pierden su capacidad para generar un tumor. ...