PharmaMar and Chugai enter into a license and commercialization agreement for PM1183 . This agreement puts in value the price of the product . Japan accounts for 10% of the global oncology market. In the current stage of development of the molecule, 1.000 million euros is the global valuation.

P.J.: PharmaMar (MSE:PHM) has announced today the signing of an exclusive license, development and commercialization agreement with Chugai Pharmaceutical Co. Ltd. (TSE:4519) for its third marine-derived anticancer drug PM1183 (lurbinectedin) in Japan. 

Under the terms of this agreement, PharmaMar will receive an upfront payment of €30 million, along with double-digit tiered royalties, and will also be eligible for receiving payments in line with the progress of the development and sales milestones; potentially worth over €100 million.

This agreement puts in value the price of the product. Japan accounts for 10% of the global oncology market. In the current stage of development of the molecule, 1.000 million euros is the global valuation. Depending on the agreements that PharmaMar reaches to close the fiscal year, it is very probable that the company's EBITDA will return positive at some point.

Lurbinectedin is PharmaMar´s third anticancer drug and is currently under development for the treatment of several types of solid tumors. 

The Company has recently completed the recruitment of patients in a Phase III study in platinum resistant ovarian cancer, and during the month of August, a pivotal Phase III trial in small cell lung cancer was initiated.

PharmaMar and Chugai Pharmaceutical Enter into a License and Commercialization Agreement for PM1183 in Japan .

MADRID and TOKYO, December 22, 2016 /PRNewswire/ --


PharmaMar (MCE: PHM) has announced today the signing of an exclusive license, development and commercialization agreement with Chugai Pharmaceutical Co. Ltd. (TSE: 4519) for its third marine-derived anticancer drug PM1183 (lurbinectedin) in Japan. Under the terms of this agreement, PharmaMar will receive an upfront payment of €30 million, along with double-digit tiered royalties, and will also be eligible for receiving payments in line with the progress of the development and sales milestones; potentially worth over €100 million.


PharmaMar will continue to conduct the clinical development activities for the first two indications of PM1183 (platinum-resistant ovarian cancer and small cell lung cancer) in Japan, whereas Chugai will make milestone payments at study initiation and will be responsible for registration filing. In addition, Chugai will have the rights to conduct clinical development in Japan to pursue additional indications and may contribute to the global development. PharmaMar will retain the exclusive production rights of lurbinectedin and will supply the API to Chugai.

PM1183 is PharmaMar´s third anticancer drug and is currently under development for the treatment of several types of solid tumors. The Company has recently completed the recruitment of patients in a Phase III study in platinum resistant ovarian cancer, and during the month of August, a pivotal Phase III trial in small cell lung cancer was initiated.
According to Luis Mora, Managing Director of PharmaMar´s Oncology Business Unit, "we are about to address our second strategic alliance with Chugai for the commercialization of a marine based anti-tumor compound. With this agreement, we will contribute to the sale of PM1183 in Japan. Meanwhile, we shall continue with the clinical development of the molecule and to advance in the upcoming regulatory steps to obtain its approval in the years to come".

"Both companies share the same value to bring PM1183 - an innovative marine based medicine to the Japanese patients so that we can contribute to the treatment," said Chugai's Representative Director, President and Chief Operating Officer, Tatsuro Kosaka. "Chugai is committed to continuously provide innovative medicines to the patients. We hope to obtain approval based on the clinical results attained so far, and also from new results that will come in the future".

Media Relations Manager (Paula Fernández +34 638 79 62 15 - pfalarcon@pharmamar.com ) and Investor Relations (+34 914444500)

SOURCE PharmaMar .

Japan - PM01183 . PharmaMar y Chugai ( Filial de Roche ) Han alcanzado un Acuerdo de Desarrollo y Comercializacion por un Monto de 30 Mill e. + Royaltis de dos digitos y podrá percibir otros pagos, potencialmente por encima de los 100 millones de euros en su conjunto por Hitos a Conseguir .

PharmaMar社と中

社と中外製薬による日本におけるPM1183に関する
ライセンスおよび販売契約の締結について

PharmaMar ha Firmado con Chugai Pharmaceutical un acuerdo exclusivo de licencia, desarrollo y comercialización de su tercer antitumoral de origen marino (PM1183) en Japón, según ha informado este jueves la compañía española a la Comisión Nacional del Mercado de Valores (CNMV).

En virtud de este acuerdo, PharmaMar recibirá un pago inicial de 30 millones de euros y 'royalties' de dos dígitos, y podrá percibir otros pagos, potencialmente por encima de los 100 millones de euros en su conjunto, en función de determinados hitos vinculados al desarrollo clínico y a las ventas.

PharmaMar continuará ocupándose del desarrollo clínico de este antitumoral en Japón para el cáncer de ovario resistente a platino y cáncer de pulmón microcítico, mientras que Chugai realizará pagos por 'milestones' al comienzo de dichos estudios y se encargará del proceso de registro.

Chugai tendrá los derechos para llevar a cabo el desarrollo clínico del antitumoral en Japón para otras indicaciones, en tanto que PharmaMar conservará los derechos de producción en exclusiva y suministrará el principio activo de este medicamento (lurbinectedina) a la compañía nipona.

PM1183 es el tercer compuesto de PharmaMar y actualmente se encuentra en desarrollo clínico para diferentes tipos de tumores sólidos.

Ésta es la segunda alianza estratégica que la española suscribe con Chugai.

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