Summary
GlobalData’s pharmaceuticals report, “Yondelis (Ovarian Cancer) - Analysis and Forecasts to 2020” provides Yondelis sales forecasts for EU5. In addition, it covers detailed clinical assessment of the drug, factors impacting drug sales, competitive landscape, and analysis of sales performance during the forecast period (2009-2020). The report also includes information on Ovarian Cancer market. This report is built using data and information sourced from GlobalData’s proprietary databases, primary and secondary research using Company’s corporate website, SEC filings, investor presentations and featured press releases, both from company and industry-specific third party sources, put together with in-house analysis, by GlobalData's team of industry experts.
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Summary
Therapy area profile including patient population for EU5
Analysis and review of Yondelis including sales data
Qualitative and quantitative assessment of market space
Analysis of the trends, drivers and restraints shaping and defining the markets
In-depth analysis of Yondelis including efficacy, safety, pricing, competition and other details which influence its sales potential
Detailed sales forecasts for 2009-2020 for Yondelis in EU
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Examine the historical sales performance of a drug in seven major markets
Obtain sales forecast for currently marketed/pipeline drug for 2011-2020 for all seven major markets
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20 octubre 2011
Noscira , Instituto Cajal , CSIC , Severo Ochoa . Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.
Journal Frontiers in Molecular Neuroscience October 2011 .
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P.D.: All Rights Reserved © 2011
Protein kinases (PK) have provided drug targets that have yielded innovative and highly effective therapeutics for cancer treatment. These include small molecule PK inhibitors such as Novartis’ Gleevec, Pfizer’s Sutent, GlaxoSmithKline’s Tykerb, and Bristol-Myers Squibb’s Sprycel. PK inhibitors now comprise over 30% of most major pharmaceutical companies’ pipelines. By 2020, small molecule kinase inhibitors are expected to collectively generate annual revenues of over $25 billion.
The success of kinase inhibitors in cancer has spurred research to develop similar compounds for other diseases including neurodegenerative disorders. But how close to the clinic are kinase inhibitors for central nervous system (CNS) diseases? Noscira has one drug candidate that is in Phase II for supranuclear palsy and is also ready to enter mid-stage trials in Alzheimer disease (AD).
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Clinical Development
Noscira is the only company with a clinical-stage kinase inhibitor for a neurodegenerative disease, however. Its candidate, a small molecule GSK-3beta inhibitor called tideglusib, has orphan drug designation in the EU and fast-track status in the U.S. Last October Noscira said it had completed recruitment for its Phase II trial in supranuclear palsy.